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At the beginning of October, pharmacists at COG member institutions raised concerns about the ability to obtain vincristine. COG quickly contacted Pfizer/Hospira, now the sole supplier of vincristine in the United States, and was told that Pfizer/Hospira was experiencing a shortage of drug due to a manufacturing delay. (The other supplier of vincristine in the US, Teva Pharmaceuticals, made a “business decision” and stopped supplying drug to the US in July of 2019.) Captain Valerie Jensen, RPh, Associate Director of the Drug Shortages Staff at the FDA reported that FDA had been contacted by Pfizer/Hospira, were exploring the drug shortage and had started working on potential solutions. more »

The unemployment rate, at 3.5 percent, is at a half-century low, and wages are rising broadly in line with productivity growth and underlying inflation. There is no evidence to date that a strong labor market is putting excessive cost-push pressure on price inflation. But despite this favorable baseline outlook, the U.S. economy confronts some evident risks in this the 11th year of economic expansion. Business fixed investment has slowed notably since last year, exports are contracting on a year-over-year basis, and indicators of manufacturing activity are weakening. Global growth estimates continue to be marked down, and global disinflationary pressures cloud the outlook for U.S. inflation. more »

Sonya Zalubowski writes: The first thing that hits you after landing in New Mexico is the vastness of the blue sky, a panorama that surrounds you amid the state’s rough high desert and mountainous landscape. Perhaps that sky with all its limitlessness, including the unrealized possibility of finding more of the gold they found in Mexico, is what first attracted the Spanish to settle this area. Their influence dating all the way to the 16th century plus the large indigenous native American presence color the area’s flavor to this day. more »

In the 1980s and 1990s, when I read women’s history on my own, I realized that there were important and prominent women in every decade, but they disappeared when the history books were written. Women were like sand castles; men were like rocks. The waters of time washed over both and wiped out the women. The Clintons — mother and daughter — are helping to remedy that. By telling the stories of 103 Gutsy women, they want to raise the sand from the beaches and fuse the particles into solid quartz. more »