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“Genomics has the potential to change reactive medicine into preventative medicine,” said Leslie Biesecker, M.D., NIH distinguished investigator, director of NHGRI’s Center for Precision Health Research and a senior author of the article. “Studying how taking a genotype-first approach to research can help us learn how to model predictive and precision medicine in the future.”
"Speier first ran for Congress in 1979, facing a crowded field in a special election for a seat formerly held by Congressman Leo J. Ryan, for whom Speier had served as a legislative aide. The special election was called after Ryan was shot to death in Jonestown, at the compound of the People’s Temple, a cult in Guyana that had previously been based in Ryan’s District. Speier traveled with Ryan on that trip in 1978 in an attempt to rescue some of the cult’s 900 members. She was left nearly lifeless on the airport tarmac after being shot five times at point blank range with an assault rifle. Speier underwent multiple surgeries after the tragedy and while recovering she realized she had a choice to make: Did she want to be a victim or did she want to be a survivor? Speier chose to be a survivor, noting that 'looking death in the face can make you fearless.'"
“Mr. Fox, and his confederate Mr. Croft, were convicted by a jury of masterminding a plot to kidnap the Governor of Michigan and to use weapons of mass destruction against responding law enforcement,” said Assistant Attorney General Matthew G. Olsen of the Justice Department’s National Security Division. “Today’s sentence reflects the Department of Justice’s unwavering commitment to protecting our elected officials, law enforcement officers, and dedicated public servants from criminal threats and violence — and to holding the perpetrators of such acts fully accountable under the law.”
Roberta McReynolds Writes: "Not a Christmas went by without the hope of discovering a brand-new box of 64 crayons to unwrap. Opening the lid released that unforgettable whiff of waxy pigments, and revealed the first glimpse of rows of those perfect tips on display that had never yet touched paper. The body of each stick was double wrapped in paper to lessen the chance of breakage. Those little paper shrouds bore the official name of each color. It was necessary to peel back the paper as the crayons wore down with usage. As I picked at the edge of the stiff paper it would inevitably slip under my short fingernails and stab the tender quick. Tearing back the paper in uneven strips ruined the perfect appearance in my eyes. One time I removed the entire paper from every single crayon to make them all uniform, and soon discovered how difficult it was to discern the differences in the darker colors. I regretted the disaster I’d created and immediately began longing for my next new box of crayons."
Jill Norgren reviews three must read books about law and justice: In Philippa Strum’s On Account of Sex: Ruth Bader Ginsburg and the Making of Gender Equality Law we learn how Ginsburg did notorious work before she became “the notorious RBG.” Ginsburg was one of the many activist women lawyers in the U.S. who have worked on behalf of issues of justice. In Lady Justice: Women, the Law, and the Battle to Save America Dahlia Lithwick introduces readers to several more, women attorneys who, during and after the Trump years, have sought justice for immigrants, would-be voters, and anti-fascist protestors among others. Rounding out these must-reads is Justice on the Brink, journalist Linda Greenhouse’s account of the U.S. Supreme Court during its 2020-2021 term when three new conservative Trump nominees along with Justices Roberts, Thomas, and Alito took full control of SCOTUS.
The new harm reduction research network will include nine research projects and one coordinating center. Grantees will investigate harm reduction strategies for their effectiveness in preventing drug overdoses and other adverse outcomes, sustainability and level of individual and community engagement. All projects will have a community advisory board and/or people with lived experience will have paid positions to support the research. Johns Hopkins University Baltimore, New York University School of Medicine New York City, Oregon Health and Science University Portland, Research Triangle Institute NC, University of Chicago, University of Nevada-Reno, University of Pittsburgh, University of Wisconsin Madison, Weill Medical College of Cornell
Based on GAO's review of regulations and information obtained from officials with the Department of Transportation (DOT) and Federal Aviation Administration (FAA), GAO found that DOT has taken steps to implement the relevant accessibility-related provisions of the FAA Reauthorization Act of 2018. For example, DOT now requires the largest U.S. airlines to report the number of wheelchairs and scooters that were transported and damaged. DOT is addressing several other provisions in the initial rulemaking processes. DOT has also taken steps to address other longstanding accessibility issues not required under the 2018 Act, but important to passengers with disabilities. In March 2022, DOT issued a proposed rule to address accessible lavatories that would apply to aircraft deliveries, to begin in 20 years. Regarding disability-related enforcement actions, DOT has taken one since 2019.
Lawrence Livermore National Laboratory: LLNL’s experiment surpassed the #fusion threshold by delivering 2.05 megajoules of energy to the target, resulting in 3.15 MJ of fusion energy output, demonstrating for the first time the fundamental science basis for inertial fusion energy. “The pursuit of fusion ignition in the laboratory is one of the most significant scientific challenges ever tackled by humanity, and achieving it is a triumph of science, engineering, and most of all, people,” LLNL Director Dr. Kim Budil said. “Crossing this threshold is the vision that has driven 60 years of dedicated pursuit — a continual process of learning, building, expanding knowledge and capability, and then finding ways to overcome the new challenges that emerged. These are the problems that the U.S. national laboratories were created to solve.” U.S. Representative Zoe Lofgren (CA-19). “This significant advancement showcases the future possibilities for the commercialization of fusion energy. Congress and the Administration need to fully fund and properly implement the fusion research provisions in the recent CHIPS and Science Act and likely more. During World War II, we crafted the Manhattan Project for a timely result. The challenges facing the world today are even greater than at that time. We must double down and accelerate the research to explore new pathways for the clean, limitless energy that fusion promises.”
"It’s customary that Treasury Secretaries provide their signature to be featured on our nation’s currency. You’d think this would be a straightforward process. But the founding fathers did not account for what seems to be a common attribute for Treasury Secretaries: terrible handwriting. My friend Tim Geithner famously had to change his signature in order to make it legible. In an interview back in 2012, he described that the change was made not for “elegance” but simply for “clarity.” President Obama joked during Jack Lew’s nomination as Secretary that he should try to make “at least one letter legible” in his signature. The good news is that President Biden did not make a similar request when he nominated me. But I’ll admit: I spent some quality time practicing my signature before submitting it to Director Olijar."
Jo Freeman reviews My People: Five Decades of Writing About Black Lives by Charlayne Hunter-Gault; nine republished pieces are about Africa and another nine are about different aspects of her personal life in the US – a stay in Harlem when she was five, returning to U.Ga nine years after she integrated it, vacationing in Martha’s Vineyard. Eleven are on women. She interviewed the famous (e.g. Nelson Mandela), the infamous (e.g. the Black Panthers) and the not famous (her grandmother).
"Enheduanna and Women of Mesopotamia, ca. 3400-2000 B.C. brings together for the first time a comprehensive selection of artworks that capture rich and shifting expressions of women’s lives in ancient Mesopotamia during the 3rd millennium B.C. These works bear testament to women’s roles in religious contexts as goddesses, priestesses, and worshippers as well as in social, economic and political spheres as mothers, workers, and rulers. Claude Gillot: Satire in the Age of Reason explores the artist’s inventive and highly original draftsmanship and places his work in the context of the artistic and intellectual activity in Paris at the dawn of a new century."
"EEOC data (for 2018 – 2020) showed representation for both minorities and women was relatively flat or marginally increased. Black and Hispanic representation remained at about 3 and 4 percent, respectively. Female representation increased from 31 to 32 percent in that period. Representatives of financial services firms and other stakeholders with whom GAO spoke for the November 2017 report (GAO-18-64) described challenges in recruiting and retaining members of minority groups and women. They also identified practices that could help address the challenges, including recruiting students from a broad group of schools and academic disciplines and establishing management-level accountability to achieve diversity goals."
Jo Freeman writes: "Georgia is one of only two states to require that elections be won by at least 50 percent of the vote. Neither Democrat Raphael Warnock nor Republican Herschel Walker received the necessary 50 percent in the November general election, when only 57 percent of Georgia voters cast a ballot. It’s ironic that both are Black men because the original purpose of the requirement for an absolute majority was to keep any Black person from being elected to high office. An electoral procedure crafted to keep Blacks out of higher office now requires that Georgia voters choose between two Black men to be their US Senator. In August of 2021 former NFL player Herschel Walker moved his residence from Texas to Georgia so he could run in the Republican primary for Senate. That’s why there will be a run-off election in Georgia on December 6."
Overall Economic Activity: Economic activity was about flat or up slightly since the previous report, down from the modest average pace of growth in the prior Beige Book period...Interest rates and inflation continued to weigh on activity, and many contacts expressed greater uncertainty or increased pessimism concerning the outlook...Inflation pushed low-to-moderate income consumers to substitute increasingly to lower-priced goods. Travel and tourism contacts, by contrast, reported moderate gains in activity, as restaurants and high-end hospitality venues enjoyed robust demand. Higher interest rates further dented home sales, which declined at a moderate pace overall but fell steeply in some districts; apartment leasing started to slow, as well.
Dr. Anthony Fauci notes that the emergence of HIV/AIDS in 1981 led to a sharp increase in interest in infectious diseases among people entering the field of medicine. Since then, infectious disease specialists have faced numerous medical challenges, including the 2009 H1N1 influenza pandemic, Ebola, Zika, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and COVID-19, he writes. Dr. Fauci notes that one success of the response was the rapid development, testing and distribution of COVID-19 vaccines thanks to years of research and investment in new and highly adaptable vaccine platforms and structural biology tools to design vaccine immunogens.
Rose Madeline Mula Writes: "Don’t be misled by the title. Brad Pitt is not my new boy toy.
Our connection is that I recently learned that he and I have something in common. Unfortunately, it’s not fame, fortune, talent or good looks. It’s a malady called Prosopagnosia. No, wait! You don’t have to move six feet away. It’s not contagious. And it’s not terminal. Unless one can actually die of embarrassment."
A bill to establish a task force on child and family economic security and stability for economic growth; A concurrent resolution expressing support for the Geneva Consensus Declaration on Promoting Women's Health and Strengthening the Family and urging that the United States be added as a signatory; A bill to extend, and provide additional support for the activities of the Department of the Interior and the Department of Justice Joint Commission on Reducing Violent Crime Against Indians; A bill to provide for the reissuance to households Supplemental Nutrition Assistance Program (SNAP) benefits to replace benefits stolen by identity theft or typical skimming practices.
"When I think of Nancy Pelosi, I think of dignity. History will note she is the most consequential Speaker of the House of Representatives in our history. There are countless examples of how she embodies the obligation of elected officials to uphold their oath to God and country to ensure our democracy delivers and remains a beacon to the world. In everything she does, she reflects a dignity in her actions and a dignity she sees in the lives of the people of this nation."
Jo Freeman Reviews: "The ones who bowed the furthest and fastest were the ones who wanted most to see and be seen with Trump; to call and be called, to hear their names in the media coupled with his. The fact that the masses loved DJT didn’t make it any easier for those who wanted his approval to hold onto a modicum of self-respect. Disagreement with Trump would lead to disparagement, and that could lead to defeat. That’s why so many Republican MCs decided it was time to retire. Two years after Trump took office, almost half of House Republicans were gone or going. A lot, but not all, were defeated in the 2018 election. By then most of Trump’s initial appointments were also gone. Sycophancy was insufficient for survival."
"GAO examined 49 aircraft and found that only four met their annual mission capable goal in a majority of the years from fiscal years 2011 through 2021. As shown below, 26 aircraft did not meet their annual mission capable goal in any fiscal year. The mission capable rate — the percentage of total time when the aircraft can fly and perform at least one mission — is used to assess the health and readiness of an aircraft fleet."
Honoring Our Veterans:"November 11 marks the annual observance of Veterans Day, a day on which we honor the courageous women and men who have served in the United States military. The National Archives is proud to have in its holdings a variety of military records, from photos to documents to searchable databases, which are available on National Archives News. NARA’s holdings regarding veterans and military records include: Veterans’ Service Records, Genealogy Research in Military Records, American Revolution, Civil War Records, World War I and World War II Records; (Note from Seniorwomen.com Editor Tam Martinides Gray:) Vietnam War | National Archives,
https://www.archives.gov/research/vietnam-war
"The CFPB has found that consumer reporting companies and some furnishers have failed to conduct reasonable investigations of consumer disputes and to spend the time necessary to get to the bottom of inaccuracies. These failures can affect, among other things, people’s eligibility for loans and interest rates, for insurance, and for rental housing and employment. “One wrong piece of information on a person’s credit report can have destructive consequences that follow a consumer for years,” said CFPB Director Rohit Chopra. “Companies that fail to properly address consumer disputes in accordance with the law may face serious consequences.”
"These ten large U.S. airlines and their regional operating partners, which operate flights for them but do not sell tickets, account for approximately 96 percent of the domestic scheduled passenger air traffic. Use the ... dashboard to learn about the amenities that the U.S. airline that you are flying on has promised to provide should there be a controllable flight cancellation or delay. You can also use the dashboard to compare amenities that the airlines commit to provide in the event of a controllable flight cancellation or delay when deciding which airline to fly."
Office of Public Affairs » News: Individuals with questions or complaints related to the ADA may call the department’s toll-free ADA information line at 800-514-0301 or 833-610-1264 (TTY) or submit a complaint through a link on the department’s ADA website, at https://www.ada.gov/.
The Justice Department announced today its plans to monitor compliance with federal voting rights laws in 64 jurisdictions in 24 states for the Nov. 8, 2022 general election. Since the passage of the Voting Rights Act of 1965, the Civil Rights Division has regularly monitored elections in the field in jurisdictions around the country to protect the rights of voters. The Civil Rights Division will also take complaints from the public nationwide regarding possible violations of the federal voting rights laws through its call center. The Civil Rights Division enforces the federal voting rights laws that protect the rights of all citizens to access the ballot.
At our house a few weeks ago, four of us sat at our kitchen table and addressed envelopes to the voters that we wanted to reach with a message from candidates! Here were some instructions: "If you want to do a VBM Chase program and win on Election Day you must get message early. A mail program accompanied with a digital campaign targeting early voters and absentee voters will give you a leg up over your competitors. When you get your mail out early to mail-in voters you can start the hard work of identifying them. But you must get your mail out or there will be nobody to identify – because they won’t know who you are. So get your mail into the early absentee voters as early as possible and target them with your emails, Facebook ads, and text messaging."
How to Win an Election by Chasing Vote by Mail Ballots
by Con…
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